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Description

Western blot analysis in HEK293T cells showed that the longer variant, ASXL1 1-645 , but not ASXL1 1-591 immunoprecipitated endogenous MLL3 and MLL4, whereas both variants immunoprecipitated endogenous BRD4 (Fig

Attempts at denervation have been described over the last 50 years and are not a new concept

What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug